Handbook Of Antithrombotic Therapy

The fourth edition of this handbook is designed to give the practitioner convenient access to practical information on established and emerging antithrombotic agents. Proper use of these agents can substantially reduce mortality and morbidity in patients with thrombotic diseases.

Whenever possible, algorithms are used to aid in dosing and monitoring antithrombotic agents. Some of these algorithms have been validated in prospective studies (pages 8 and 9) whereas others (pages 30-37) are derived from widespread experience. The reader should keep in mind that these algorithms are recommendations and not rigid practice guidelines. The reader will also find flow charts to help in the diagnostic approach to important thrombotic diseases including pulmonary embolism (PE), deep venous thrombosis (DVT), atrial fibrillation (AF), and myocardial infarction (MI).

Table Of Contents

Heparin

Introduction
Indications and Precautions
Dosing and Therapeutic Ranges
Guidelines for Overlapping Heparin and Warfarin
Monitoring and Dose Adjustment
Weight-Based Monitoring and Dose Adjustment
Prevention of Deep Venous Thrombosis/Pulmonary Embolism
Bleeding in Patients Receiving Heparin.
Determining the Therapeutic Range of Heparin
Evaluation of Patients with Suspected Deep Venous Thrombosis
Evaluation of Patients with Suspected Pulmonary Embolism

Low Molecular Weight Heparins and Danaparoid

Introduction
Indications and Dosing

Warfarin

Introduction
Indications and Precautions
Drug Interactions with Warfarin
INR Considerations
Initiating Warfarin Therapy
Monitoring and Dose Adjustments
Managing Warfarin in Patients Undergoing Surgery
Bleeding in Patients on Warfarin
Prevention of Deep Venous Thrombosis/Pulmonary Embolism
Evaluation of Patients with Atrial Fibrillation

Aspirin

Introduction
Dose Regimens
Indications and Precautions

Clopidogrel

Introduction
Indications and Precautions

Ticlopidine

Introduction
Indications and Precautions

Aspirin - Extended Release Dipyridamole

Platelet Glycoprotein IIb/IIIa Inhibitors

Abciximab
Eptifibatide
Tirofiban

Thrombolytic Agents

Introduction
Indications and Precautions
Dosing in Myocardial Infarction
Rapid Evaluation of Patients with Acute Myocardial Infarction.
Dosing tPA (alteplase) in Acute Ischemic Stroke
Dosing in Pulmonary Embolism/Deep Venous Thrombosis
Managing Heparin and Thrombolytic Therapy
Other Regimens

Lepirudin and Argatroban in Acute Heparin Induced Thrombocytopenia

Antithrombotic Therapy During Pregnancy

Additional Reading

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